Hi,
Firstly you should not include dots before extensions in the property:
 
ExcludedExtensionsForPreview = "pdf, xls, doc, docx"
This way the property would work as expected but you would still need to list all extensions (no match-all setting here).
 
For disabling all previewing, instead you should deny Preview permission for your root folder:
 
var rootFolder = new FileManagerRootFolder
{
    Name = "My root folder",
    Location = "c:\root\folder"
};
rootFolder.AccessControls.Add(new FileManagerAccessControl
{
    Path = @"\",
    AllowedPermissions = FileManagerPermissions.Full,
    DeniedPermissions = FileManagerPermissions.Preview
});      
fileManager.RootFolders.Add(rootFolder);